Megan Sykes, United States

Columbia Center for Translational Immunology
Columbia University Medical Center

Megan Sykes, MD

Dr. Sykes is the Michael J. Friedlander Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery), Columbia University. She is Director of the Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons. She also serves as Director of Research for the Transplant Initiative and Director of Bone Marrow Transplantation Research at Columbia University Medical Center. Dr. Sykes joined Columbia University in April, 2010 after spending 19 years at Massachusetts General Hospital/Harvard Medical School, where she was the Harold and Ellen Danser Professor of Surgery and Professor of Medicine (Immunology) and Associate Director of the Transplantation Biology Research Center.

Dr. Sykes’ research career, during which she has published >4210 papers and book chapters, has focused on hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes. She has developed novel strategies for achieving GVL effects without GVHD following hematopoietic cell transplantation (HCT). One such approach provided safety and efficacy data in clinical trials of non-myeloablative haploidentical HCT that permitted of the use of HCT for the intentional achievement of organ allograft tolerance in humans. Dr. Sykes dissected mechanisms and pioneered minimal conditioning approaches for using HCT to achieve allograft and xenograft tolerance. She devised an approach to identifying and tracking the alloreactive T cell receptor repertoire in human transplant recipients. Her work on xenogeneic thymic transplantation for tolerance induction permitted long-term kidney xenograft survival in non-human primates. She has extended the HCT approach to the problem of reversing autoimmunity while replacing destroyed islets of Langerhans in Type 1 diabetes and developed novel “humanized mouse” models that allow personalized analysis of human immune disorders and therapies.

Dr. Sykes is Past President of the International Xenotransplantation Association, past Vice President of the Transplantation Society, has repeatedly been a member of TTS Council and is a member of the National Academy of Medicine.


Lectures by Megan Sykes


Committee Role Section
Scientific Program Committee Member

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